Principal Engineer (Filling) Jobs in USA 2026 with Visa Sponsorship

A high level engineering opportunity is available in Pleasant Prairie, Wisconsin, United States, for a Principal Engineer in Filling operations. This role offers a chance to work with Eli Lilly, a global healthcare leader focused on delivering innovative medicines. It is designed for experienced engineering professionals who want to lead advanced pharmaceutical manufacturing processes and improve patient outcomes worldwide.

The hiring organisation, Eli Lilly and Company, is a globally recognised pharmaceutical company headquartered in the United States. Additionally, the company is committed to discovering, developing, and delivering life changing medicines that improve global health outcomes. Lilly strongly promotes innovation, inclusion, and scientific excellence across its workforce. Furthermore, it actively supports community development through philanthropy and employee volunteer initiatives.

This role focuses on aseptic filling, sterilisation, and sterile drug product handling within a regulated manufacturing environment. Moreover, the engineer serves as a technical leader responsible for ensuring safe, efficient, and compliant production processes. The position also involves driving process improvement initiatives and supporting equipment reliability across manufacturing systems. In addition, the role includes mentoring junior engineers and collaborating with cross functional teams to achieve operational excellence.

Job Duties

• Provide technical leadership in aseptic filling, sterilisation, and sterile drug product manufacturing processes.
• Monitor process performance using data analysis and drive continuous improvement initiatives.
• Ensure equipment reliability, calibration, and maintenance activities meet regulatory requirements consistently.
• Lead root cause analysis for production issues and implement effective corrective actions.
• Support audit readiness and act as a key technical contact during regulatory inspections.
• Develop and manage capital project scopes and support technology transfer initiatives.
• Identify process bottlenecks and recommend improvements aligned with business objectives.
• Review technical documentation for accuracy and compliance with engineering standards.
• Mentor junior engineers and support training across manufacturing and quality teams.
• Collaborate with cross functional teams including quality assurance and manufacturing operations.

Job Requirements

• Bachelor’s degree in Engineering or related technical discipline is required.
• At least eight years of senior engineering experience in pharmaceutical manufacturing environments required.
• Minimum five years of aseptic filling operations experience in regulated industries required.
• Strong understanding of regulatory compliance standards within pharmaceutical manufacturing required.
• Experience in equipment troubleshooting and process validation highly preferred.
• Proven ability in technical leadership, problem solving, and project management required.
• Strong communication skills for cross functional collaboration and documentation review required.
• Experience with manufacturing execution systems and quality management systems preferred.
• Ability to manage multiple priorities in a fast paced production environment effectively required.

#339966;">#339966;" href="https://www.simplyhired.com/job/pQCBgZ_MQupHgIK4s9G4vc1wf5Dcc4jgD6r3reaGMj9KpuTqt7MGcg" target="_blank" rel="noopener">Click Here to Apply

Conclusion

This role offers a strong platform for senior engineers seeking leadership in pharmaceutical manufacturing innovation. Interested candidates can apply and contribute to advancing global healthcare through high quality medicine production.

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