Principal Systems Engineer (CAS) Jobs in USA 2026

Ready to lead systems engineering for technology that treats abnormal heart rhythms? Medtronic seeks a Principal Systems Engineer for its Cardiac Ablation Solutions business in Mounds View, Minnesota. Work authorization sponsorship, including H-1B, TN, and J, is offered for Principal-level roles. If complex, patient-focused medical device engineering excites you, this role offers real technical leadership.

About the Role

You will lead systems engineering for complex, multidisciplinary medical device programs. This includes turning clinical and customer needs into clear system-level design inputs. Additionally, you will define system architecture, interfaces, requirements, and traceability across hardware, software, and disposables.

You will also lead risk management, verification and validation, and technical design reviews. The role spans the full product lifecycle, from early concept through post-market support. It is onsite four days a week, with less than 10% travel.

About the Hiring Firm

Medtronic is a global healthcare technology leader with about 95,000 employees in over 150 countries. Its Cardiac Ablation Solutions business develops cardiac mapping and ablation technologies for abnormal heart rhythms. Medtronic acquired Affera, a mapping and ablation company, in August 2022.

The FDA approved the Affera system with the Sphere-9 catheter in 2024. That catheter delivers both pulsed field and radiofrequency energy. Medtronic’s technologies improve the lives of more than 72 million patients each year.

Job Duties

• Lead systems engineering for complex medical device programs
• Define system architecture, interfaces, and performance budgets
• Manage requirements development and end-to-end traceability
• Integrate safety, usability, cybersecurity, and software risk into design
• Establish system verification and validation strategies
• Lead design reviews, trade studies, and root-cause investigations
• Mentor systems engineers and build reusable methods

Job Requirements

• Bachelor’s degree in Engineering, Physics, or a related field
• 7+ years’ relevant experience, or a master’s with 5+, or a PhD with 3+
• Medical device or other regulated industry experience preferred
• Cardiac electrophysiology, ablation, or catheter experience preferred
• Experience with requirements tools such as Polarion, Jama, or DOORS preferred
• Mentoring and technical leadership experience across distributed teams preferred

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Conclusion

This role suits senior systems engineers ready to shape life-saving cardiac technology. With strong pay and Principal-level sponsorship, the package is substantial. For experienced engineers seeking impact, Medtronic offers a rewarding path.

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